Ozempic Side Effects 

Estimated reading time: 35 minute(s)

Ozempic is a prescription medication that contains the active ingredient semaglutide and is primarily used for treating type 2 diabetes. The medicine helps individuals with the condition to achieve better glycemic control and potentially experience weight loss as a secondary effect. The medication works by mimicking the action of a certain hormone that regulates blood sugar levels and promotes the feeling of fullness.

Although it is advised to use the medicine as a healthcare provider recommends, many people have been using it without supervision. Ozempic has gained attention for its potential off-label use in promoting weight loss. While the medicine has shown promising results in clinical trials for weight management, it is essential to exercise caution when considering its use for weight loss without a prescription. Using the medicine without supervision can cause multiple Ozempic side effects on physical and mental health. 

What Are The Dangers Of Ozempic – Common Side Effects

Using Ozempic without professional supervision for weight loss or any reason can cause various side effects, including:

Physical Side Effects

Gastrointestinal Effects

One of the most common side effects of Ozempic is gastrointestinal discomfort. You may experience nausea, vomiting, diarrhea, or constipation. These symptoms are usually mild to moderate in severity and tend to improve over time as the body adjusts to the medication. However, in some cases, they can be persistent and bothersome.


While weight loss is a potential benefit of Ozempic, it can also increase the risk of hypoglycemia (low blood sugar).[1] The risk is higher when Ozempic is combined with other diabetes medications that can lower blood sugar levels. Symptoms of hypoglycemia include dizziness, shakiness, sweating, confusion, and in severe cases, loss of consciousness.


There have been reports of pancreatitis (inflammation of the pancreas) in individuals using GLP-1 receptor agonists, such as Ozempic.[2] Ozempic pancreatitis symptoms may include severe abdominal pain that radiates to the back, nausea, vomiting, and fever. Medical attention should be sought immediately if these symptoms occur, as pancreatitis can be a serious and potentially life-threatening condition.

Thyroid C-Cell Tumors

In preclinical studies, semaglutide has been associated with developing thyroid C-cell tumors in rodents.[3] It is currently unclear whether the same risk exists for humans, but certain populations with cancer risk are generally advised to avoid the medicine.

Allergic Reactions

Although rare, allergic reactions to Ozempic can occur. Symptoms may include itching, rash, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing. If any signs of an allergic reaction are observed, immediate medical attention is necessary.

Mental Side Effects

In addition to the physical side effects mentioned previously, the medicine may cause potential mental effects. Some individuals may experience mental health-related changes while taking the medication, such as:

  • Mood Changes: Some individuals have reported experiencing mood swings, irritability, feelings of depression or anxiety, and even being suicidal while using Ozempic.[4] These changes may be temporary and resolve as the body adjusts to the medication.
  • Cognitive Function: Some people have reported cognitive effects while using Ozempic. These can include difficulties with concentration, attention, or memory. The cognitive changes are generally mild and may not affect everyone.
  • Disordered Eating Behaviors: While Ozempic can promote weight loss, it is essential to be mindful of its potential impact on eating behaviors. Some individuals may develop disordered eating patterns, such as obsessing over food, restrictive eating, or an unhealthy preoccupation with weight loss.

Remember that the physical and mental effects of the medicine may vary from person to person. Any person using Ozempic under supervision is less likely to experience side effects than those using the medication off-label.

Who Is At Higher Risk Of Having Semaglutide Side Effects

Certain individuals may be at a higher risk of experiencing side effects from Ozempic compared to others. While the following factors do not guarantee the occurrence of adverse effects, they may increase the likelihood:

  • Pre-existing Conditions: Individuals with certain pre-existing conditions may be at a higher risk of experiencing side effects. For example, individuals with a history of gastrointestinal disorders, such as inflammatory bowel disease or gastroparesis, may be more prone to gastrointestinal discomfort, such as Ozempic stomach pain. Similarly, individuals with a history of pancreatitis, thyroid issues, or a family history of medullary thyroid carcinoma (MTC) may be at a higher risk for developing complications related to those conditions.
  • Medication Interactions: Certain medications can interact with Ozempic, potentially increasing the risk of side effects. For example, medications that lower blood sugar, such as insulin or sulfonylureas, can increase the risk of hypoglycemia when combined with Ozempic. Remember to inform your healthcare provider about all your medications to ensure they can assess potential interactions and adjust your treatment plan accordingly.
  • Individual Sensitivity: People’s bodies may react differently to medications, including Ozempic. Some individuals may be more sensitive to the effects of the medication and, therefore, more prone to experiencing side effects.
  • Age and Health Status: Older individuals or those with compromised liver or kidney function may be more susceptible to the side effects of Ozempic.

How Long Do Ozempic Side Effects Last?

The duration of semaglutide side effects can vary among individuals. Not everyone will experience the same side effects, and the intensity and duration of side effects can differ. [5] However, here are some general considerations regarding the duration of Ozempic side effects:

Initial Weeks

During the initial weeks of starting Ozempic, individuals may experience gastrointestinal side effects. These symptoms are typically more prominent during this period. However, for many people, these side effects tend to improve or resolve as the body adjusts to the medication.

Subsequent Months

As treatment continues, the frequency and intensity of gastrointestinal side effects may decrease. Many individuals report that these side effects become more manageable or even subside completely with the ongoing use of Ozempic. Maintaining good hydration and following dietary recommendations to support symptom management is essential.

Individual Variations

The duration of side effects can vary depending on factors such as individual sensitivity, overall health status, and adherence to lifestyle modifications. Some individuals may experience side effects for a shorter duration, while others may have a longer adjustment period. Communicating any concerns or persistent side effects with your healthcare provider is essential when using the medicine.

Persistence of Other Side Effects

While gastrointestinal side effects are commonly reported, other side effects such as injection site reactions, decreased appetite, or mood changes may also occur. The duration of these side effects can vary among individuals. If you experience persistent or concerning side effects, talk to your healthcare provider for appropriate evaluation and guidance.

When using Ozempic for weight loss, diabetes management, or any other reason, remember to have regular follow-up appointments with your healthcare provider. Consistent medical supervision can help you avoid and manage adverse reactions and adjust your usage and dose accordingly.

Managing Ozempic Side Effects- What To Do

If you are experiencing side effects from Ozempic while using it for weight loss or any other purpose, seek help immediately to ensure your safety. Here are some actions you can consider if you encounter side effects:

Contact your healthcare provider

If you are experiencing side effects, contact your healthcare provider promptly. They are familiar with your medical history and can provide personalized guidance. Your doctor can evaluate the severity of the side effects, determine whether they require medical attention, and advise you on the appropriate course of action.

Follow medical advice

Your healthcare provider may recommend adjusting the dosage of Ozempic or discontinuing its use altogether, depending on the severity and nature of the side effects. Adhere to their instructions strictly.

Manage symptoms

If the side effects are manageable and not severe, your healthcare provider may suggest strategies to alleviate symptoms. For example, if you are experiencing Ozempic stomach pain, they may recommend dietary modifications, such as eating smaller, more frequent meals or avoiding certain foods that trigger the symptoms. Following their guidance can help mitigate the side effects and improve comfort.

Seek additional support

If you are experiencing mental health-related side effects, such as mood changes or anxiety, it can be beneficial to seek additional support. Consult with a mental health professional who can provide guidance and strategies to manage these effects effectively. They can work in collaboration with your healthcare provider to ensure comprehensive care.

Monitor blood sugar levels

If you are using Ozempic for weight loss while managing diabetes, monitor your blood sugar levels closely. The medication can lower blood sugar, potentially leading to hypoglycemia. Regular monitoring can help you identify and address any fluctuations in your blood sugar levels.


Can Ozempic cause muscle pain?

Muscle pain is not a commonly reported side effect of Ozempic. If you experience muscle pain while taking Ozempic, it is important to consult your healthcare provider to determine the cause and appropriate management.

Is Ozempic a type of insulin?

No, Ozempic is not a type of insulin. It belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. Ozempic mimics the action of a naturally occurring hormone called GLP-1 to help lower blood sugar levels and promote weight loss.

Can I stop taking Ozempic altogether?

Do not stop or adjust the dosage of Ozempic without consulting your healthcare provider. Abruptly discontinuing Ozempic can adversely affect your blood sugar control and overall health. Your healthcare provider will work with you to develop a plan if and when it is appropriate to discontinue the medication.

Will I regain weight after discontinuing Ozempic?

Weight loss achieved while taking Ozempic may vary among individuals. When discontinuing the medication, it is possible to regain weight if healthy lifestyle habits, such as a balanced diet and regular exercise, are not maintained. It is crucial to discuss weight management strategies with your healthcare provider.

What happens when a pregnant woman takes Ozempic?

Ozempic is not recommended for use during pregnancy. Studies on the safety of Ozempic in pregnant women are limited, and there may be potential risks to the developing fetus. If you are pregnant, planning to become pregnant, or breastfeeding, inform your healthcare provider before using Ozempic.

Can long-term Ozempic use cause death?

While Ozempic is generally considered safe when used as prescribed and under medical supervision, like any medication, rare but serious side effects are possible. These side effects can include pancreatitis, severe allergic reactions, cardiovascular events, or other complications. However, the risk of death from using Ozempic is minimal. If you have any concerns with using the medicine, discuss them with your healthcare provider.

Can I take Ozempic if I have other medical conditions?

The use of Ozempic may need to be evaluated if you have certain medical conditions, such as pancreatitis, thyroid issues, kidney problems, or a history of allergic reactions. It is essential to inform your healthcare provider about all your medical conditions before starting Ozempic to ensure its safe and appropriate use.


1 Clinical Review Report: Semaglutide (Ozempic): (Novo Nordisk Canada Inc.): Indication: For the treatment of adult patients with type 2 diabetes mellitus to improve glycemic control, in combination with metformin (second-line treatment), and in combination with metformin and sulfonylurea (third-line treatment) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019 Jun. Results. Available from:

2 Smits MM, Van Raalte DH. Safety of Semaglutide. Front Endocrinol (Lausanne). 2021 Jul 7;12:645563. doi: 10.3389/fendo.2021.645563. Erratum in: Front Endocrinol (Lausanne). 2021 Nov 10;12:786732. PMID: 34305810; PMCID: PMC8294388.

3 Funch D, Mortimer K, Ziyadeh NJ, D Seeger J, Zhou L, Ng E, Ross D, Major-Pedersen A, Bosch-Traberg H, Gydesen H, Dore DD. Risk of Thyroid Cancer Associated with Use of Liraglutide and Other Antidiabetic Drugs in a US Commercially Insured Population. Diabetes Metab Syndr Obes. 2021 Jun 10;14:2619-2629. doi: 10.2147/DMSO.S305496. PMID: 34140791; PMCID: PMC8203194.

4 Chao AM, Tronieri JS, Amaro A, Wadden TA. Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations. Drug Des Devel Ther. 2022 Dec 29;16:4449-4461. doi: 10.2147/DDDT.S365416. PMID: 36601368; PMCID: PMC9807016.

5 Smits MM, Van Raalte DH. Safety of Semaglutide. Front Endocrinol (Lausanne). 2021 Jul 7;12:645563. doi: 10.3389/fendo.2021.645563. Erratum in: Front Endocrinol (Lausanne). 2021 Nov 10;12:786732. PMID: 34305810; PMCID: PMC8294388.

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